Heart Failure

Heart Failure (HF) is a devastating disease that affects more than 12.1 million HF patients and 3.0 million incident HF patients over 25 years old in China. Both prevalence and incidence increased with increasing age (0.57%, 3.86%, and 7.55% for prevalence and 158, 892, and 1655 per 100,000 person-years for incidence among people who were 25, 65, and 80 years of age, respectively). However, the WHO has discovered a 29% increase in total heart disease deaths in Pakistan in only three years, totaling around 406,870 each year. and for 300,000 Australians and 11 million people in the US and Europe, with an incidence of 1.1 million new cases per year. Furthermore, HF incidence is expected to rise by 40% by 2040 based on current growth rates.
According to the US National Institutes of Health (NIH), 100,000 patients could immediately benefit from a ventricular assist device (VAD) or total artificial heart (TAH), and the European market is similarly sized. Without intervention, patients with severe HF have a bleak outlook. For these patients, drug therapy is a limited, relatively ineffective option. Although a heart transplant would meet their needs, only 4,000 donor hearts are available globally each year.


Total Artificial Heart Therapy

Patients with end-stage HF who require support while waiting for a heart transplant or who are not candidates for a transplant may benefit from having a TAH implanted. The device can fully replace the function of the natural heart by removing the ventricles.

TAH

Upplysning Robotics is a complete artificial heart designed to take over the entire function of a failing heart in a patient. The image below depicts a high-level overview of an ascending robotic TAH. Upplysning Robotics will introduce one motor, Magnetic Levitation, combined with hydraulic technology to reduce the size of the artificial heart, an integrated chip with a  processor, and an analogue circuit inside the artificial heart that will outperform other TAHs designed by different companies.

Powerful

The pumps can provide high flows of over 10 to 12 lpm for dynamic activity.

Smart

The Smart Low Power controls the pump operation to changes in the patient's activity.

Durable

An anticipated device life of up to 10 years or more.

Small

Small enough for a child, powerful enough for an adult.

Portable

A small external controller and batteries to give patients freedom.

TAH

Upplysning Robotics is a complete artificial heart designed to take over the entire function of a failing heart in a patient. This image below is the top of Upplysning Robotics' TAH, which will have an integrated chip inside. Upplysning Robotics makes better and stronger body structures smaller with the magnetic levitation technique to make them more reliable and makes custom-designed MCUs, especially for the artificial heart, that will be more efficient, fast, less error-prone, lower in delay, and low in power.

Blood flow

It has self-regulated blood flow, Automatic response to different loading conditions, Can handle high afterload pressures (Aortic, Pulmonary).

Biocompatibility

It has No rejection, No need for Immunosuppression, Minimal anticoagulation.

Longevity

To be established via long-term reliability durability..

Accessibility and Small

Limited by production. Small enough for a child, powerful enough for an adult.

Portable

A small external controller and batteries to give patients freedom..

The picture above shows an ASIC MCU chip fabricated with an international standard processor and integrated with a custom-designed ASIC IP on a PCB board that acts as a test bench. Chipmotion Limited in China and Prof. Dr. Mehdi Khan were responsible for designing and producing this ASIC chip. This type of MCU will be integrated inside an artificial heart to make it super intelligent and capable of reading body behaviour such as ECG, PCG, heartbeat, temperature, and so on. And the external controller can see everything through the Bluetooth IP function of an artificial heart implanted inside the human body.

Upplysning Robotics TAH

A Single Moving Part

Magnetic levitation placed on a single rotor provides perfusion to the left and right sides of the body.

Advantages of a External Components

2 outlet conduits allowing to connect the prosthesis to the pulmonary artery and aorta. One percutaneous driveline connecting the prosthesis to external components.

Physiologic Interaction

The device’s patented left-right flow-balancing system allows dynamic adaptation to changes in the patient’s physiology.2 ventricles chambers, separated into two parts by a membrane, one for the blood and one for the actuator fluid. The blood-contacting layer of this membrane is made of biocompatible materials. One flexible external bag contained the actuator fluid.

Active Magnetic Levitation and hydraulic pump

Magnetic levitation provides precise, stable operation with no mechanical wear. And also One motor pump group composed of 2 micro pumps that push the actuator fluid to the membranes and generate the systole and diastole.

Blood Compatibility and Valves

Special large gaps within the pump reduce blood-cell damage and the risk of clotting.4 biological valves at the inlet and outlet providing unidirectional pulsatile blood flow.

Microprofessors

Embedded electronics, microprocessors, and integrated sensors allow autoregulated responses to the patient's physiological needs. Upplysning Robotics will create a custom-designed MCU specifically for artificial hearts rather than for general purposes, as designed by other TAH companies, to make it more reliable, low-power, less delayed, and more efficient as an embedded controller inside the human body rather than outside the body.


An example of FDA-approved TAH animation does not belong to Upplysning Robotics TAH. Upplysning Robotics is designing its own animated TAH and will soon upload it to this website.  UR will design a far superior TAH with a combination of magnetically levitated hydraulic pumps and integrated chips. Additionally, Upplysning Robotics uses a tiny radioactive battery that can last 50 years without recharging. 

The Upplysning Robotics artificial heart is distinct from other artificial hearts in that it will be fully integrated within the human body with no external electronics devices or batteries. So Upplysning Robotics has its own custom-designed MCU integrated within an artificial heart inside the human body. And it will use a tiny radioactive battery that can last 50 years without recharging inside the human body. The above diagram shows the MCU specification for the development of the TAH.



The Upplysning Robotics system comprises a custom-designed MCU, as shown above, with a built-in processor, especially for open-source RISC-V and AndesCore A27 Single Core, along with custom-designed IP like ECG, PCG, Heart Rate, Cardiac Output, Temperature Sensor, Battery Sensor, and Bluetooth Enable Technology. Also, design a custom-designed motor driver IC specially for the artificial heart to drive the motor accurately. It will make it more efficient with low power, less delay, and more accuracy as compared to other total artificial hearts with general-purpose MCUs. It will also have a better body structure that will be durable and biocompatible. Also, it will use one more magnetic levitation pump rotor that is magnetically levitated between opposing pump casings. The key feature that enables this device to support both the left and right sides of the heart is the left and right impeller blades, which are mounted on either side of the rotating hub. When you combine the impellers' dedicated hydraulic design with cutting-edge magnetic levitation (MAGLEV) technology and a hydraulic pump, you can fine-tune the circulation by changing the amount of fluid that comes out.

An external Bluetooth-enabled controller connected to a custom-designed MCU specifically designed for TAH and battery sensors powers the internal device via a percutaneous driveline. A tiny radioactive battery that can last 50 years without recharging uses a magnetic field to create energy and can also use nuclear batteries that can last for years. 




About Us



Prof. Dr. Mehdi Khan and his supervisor, Prof. Dr. Professor Lin, appeared on the news to talk about our microelectronics laboratory at the University of Science and Technology of China. It came on Chinese television and took a laboratory faculty member's interview.

Upplysning Robotics SMC PVT LTD. is a privately held company founded on June 17, 2020 by a group of doctors. Our staff includes world-class engineers and medical specialists who are diligently working to advance this ground-breaking technology. Together, we have established a strong collaborative network that extends both nationally and internationally. Our world headquarters are located in Punjab, Lahore, Pakistan.

Meet The Team

We are all around the world!

Muhammad Khalid Pervaiz, MBBS

CEO (chief executive officer)

Dr. Muhammad Khalid Pervaiz is working as the CEO of this company. He received his MBBS from King Edward Medical College and also worked as the director of Aitemad Hospital from 1999 to 2010. He is a pediatric and cardiology physician, and he practices in a private clinic named the Aitemad Clinic. He has more than 45 years of medical experience.

Professor Mehdi Khan, MEE, PhD

Chief Technical Officer

Professor Dr. Mehdi Khan is the co-founder and chief technology officer of "Upplysning Robotics." Dr. Mehdi Khan has been awarded a doctorate in engineering with a specialisation in IC design by the University of Science and Technology of China. During his doctoral studies in China, he also got a scholarship to work as a visiting scholar at the National University of Singapore in Singapore for 6 months (Dr. Mehdi Khan did not go to Singapore for some reason) and has over 3 years of experience with cleanroom nanofabrication for micro-nano device design characterization, mems sensors, THz receivers like antennas, couplers, HEB mixers, 2D transistors, and passive component device modeling. Also, work on RFIC/MMIC and ASIC chip tapeout from foundries is available for nodes ranging from 180 nm to the lowest nodes using different foundries. During his PhD, Dr. Mehdi worked in a Chinese Silicon Valley company as the CTO (President) of Anhui Transilica Microelectronics Co. Ltd., where he worked on ASIC/Analogue design and IP integration, including IP processors, WiFi, and BLE, among other things, to develop an MCU, as well as designing projects such as RFIC, MMIC, and a custom-designed MCU for driveless smart cars in a specific city. The world's 7th largest fibre optics manufacturer, Hengtong Group, acquired the ATM. Dr. Mehdi started working on the same project at the new company in Suzhou, China, as vice president of engineering. Secondly, Dr. Mehdi graduated from Chalmers University of Technology in Sweden with a master's degree in electrical engineering with a specialisation in biomedical and radio astronomy. Dr. Mehdi Khan took admission in the biomedical engineering programme, in which he joined the company Medfied Diagnostics AB and learned about breast cancer detection and stroke detection in the company, which also involved designing an ECG and testing it on humans. In addition, Dr. Mehdi also took courses in anatomy, physiology, and biomaterials. Dr. Mehdi took a second programme at Chalmers University of Technology in wireless and photonics engineering. During his second master's degree in wireless and photonics engineering, he concentrated on IC design and THz circuits and worked in a cleanroom for THz devices designed for healthcare and radio astronomy. Dr. Mehdi Khan conducts research for THz devices in a cleanroom for the NASA joint laboratory, the Jet Propulsion Laboratory, and Sweden's Onsala Space Observatory. Dr. Mehdi Khan also worked for Ericsson on a master's programme project on the transceiver using USRP. Further, Dr. Mehdi went to England for a BSc in computer science at the University of Bedfordshire, Luton, UK, and has taken some courses in computer science like programmeming, data structure, psychology, and English language in the bachelor ogram. Dr. Mehdi Khan left the UK, transferred credits from UK university courses to Pakistan University, and joined the university in Pakistan to complete his bachelor's degree in electrical and electronics engineering. Moreover, he worked on digital stethoscopes during and after his undergraduate degree in Pakistan as a biomedical engineer at Aitemad Hospital. And, as of now, Dr. Mehdi Khan is working as a senior consultant in total artificial heart design at Upplysning Robotics and at the Heart Organ Transplant Institute abroad. He is working with a cardiac physician and surgeon on total artificial heart design and transplantation. Dr. Mehdi is also developing a digital stethoscope with noise cancellation, an amplifier, Bluetooth, and the ability to connect with mobile devices and do AI DL to detect heart arrhythmias automatically and guide doctors heart sounds. Dr. Mehdi is a patron of the International Society of Medical, Electronics, and Mechanical Circulatory Support and has also worked as a patron for the Journal of Medical, Electronics, and Mechanical Circulatory Support. In addition, he is the co-founder of the Aitemad Advanced Cardiovascular Research and Development Hospital for artificial heart transplants, along with medical doctors in Pakistan .

Professor Pervaiz Akhtar Chaudhry MD, FACS

Head of Cardiology Department

When I came to Valley Cardiac Surgery after completing an extensive training in heart surgery at UCLA in cardiothoracic surgery (adult and pediatric transplant, robotics, minimally invasive, mechanical devices, and all traditional heart procedures), I had fallen in love with California and was given the opportunity to come to Fresno and actually do heart surgery. I quickly went from graduate fellow to partner and then became the managing partner as our practice grew. During this time, I played a pivotal role in creating all new programs in the Central Valley (TAVR, lung nodule, off-pump CABG, high-risk cardiac surgery, minimally invasive CABG, mechanical circulatory support program (LVAD, ECMO)) and continued to develop, evolve, and innovate better techniques in minimally invasive heart surgery.?32 billion is the cost of heart failure in the US alone. We can curb that cost and benefit the patient through a faster recovery. Recovery and risk are often decreased if we can do these complex heart surgeries in a minimally invasive way. Innovation and experience are keys to better results for our patients. Returning to a normal life faster also helps combat depression and the financial hardship that can result from being out of work for a long time. With our commitment to the community, we believe in understanding all aspects that have an impact on our patients' heart conditions. We currently do 19 different minimally invasive heart surgeries at VCS. While some believe that complex heart surgery cannot be done minimally invasively, we humbly disagree. We founded AIMHS, the American Institute of Minimally Invasive Heart Surgery. Our intention with AIMHS is to educate heart surgeons globally on how to perform heart surgery minimally invasively because the benefits to patients, their families, and society are enormous and heart surgery has evolved.

Scientific Advisory Board

  • CTO, Professor Mehdi Khan, MEE, PhD (see above)
  • Professor He Lin, PhD
  • Professor Lin Fujiang, PhD

Clinical Advisory Board

  • Professor Pervaiz Akhtar Chaudhry MD, FACS (see above)
  • CTO, Professor Mehdi Khan, MEE, PhD (see above)
  • Professor, Zhi-Cheng Jing, MD, PhD
  • CEO, Muhammad Khalid Pervaiz, MBBS (see above)

Affiliated Hospital and Research laboratory

  • Aitemad Advanced Cardiovascular Research and Development Hospital
  • United Christian Hospital
  • Peking Union Medial University
  • Aitemad Hospital/Clinic

Careers

Upplysning Robotics is always accepting applications from motivated medical doctors (cardiac surgeons or physicians), electrical engineers, and scientists to work on a remotely or contractual basis.

Please send us your application documents via LinkedIn or email.

Journal of Medical, Electronics and Mechanical Circulatory Support

Upplysning Robotics is associated with the Journal of Medical, Electronics and Mechanical Circulatory Support.

Journal Link Open The Journal

International Society of Medical, Electronics and Mechanical Circulatory Support

Upplysning Robotics is associated with the International Society of Medical, Electronics and Mechanical Circulatory Support.

ISMEMCS Link Open The ISMEMCS




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Corporate Office

Upplysning Robotics, SMC PVT LTD.
Office Number 30, Block H, Phase 6, DHA, Lahore
54792, Pakistan
Email: info@upplysningavancez.com
Website: https://www.upplysningavancez.com

Hospital

Aitemad Advanced Cardiovascular Research and Development Hospital
Main G.T.Road, Jallomore, Beside Ghalla Mandi, Batapur, Lahore
54000, Pakistan
Email: info@aitemad.upplysningavancez.com
Website: https://www.aitemad.upplysningavancez.com

Foreign Hospital Office

Peking Union Medical College
5 Dong Dan San Tiao, Beijing, 100005 Beijing, Beijing, China
Email: info@upplysningavancez.com Website: https://www.pumch.cn/en/introduction.html

University Collaboration

University of Science and Technology of China
No.96, JinZhai Road Baohe District, Hefei, Anhui,
230026, P.R.China
Email: mehdi@mail.ustc.edu.cn
Website: https://www.ustc.edu.cn